Stemshot

The umbilical cord blood carries all the necessary nutrients, stem cells, and growth factors to a developing baby throughout the entire nine months of gestation, making cord blood stem-cell suspensions of high value in regenerative medicine procedures. StemShot® cell suspensions have a very high percentage of live cells, due to their proprietary isolation and cryopreservation methods. The distinct immunological characteristics of the umbilical cord blood contained in StemShot® give it high utility as an allograft. These cells are not readily recognized by the recipient’s immune system; hence, the body accepts them, rather than rejecting them as foreign, transplanted cells.

AmnioShot leverages the intrinsic healing properties of amniotic fluid for clinical applications. Derived from the amniotic membrane and amniotic fluid of donated birth tissues, AmnioShot is intended to be used to promote healing and prevent scarring and infection in a number of scenarios, some of which include wound healing, burns, and various surgeries.

AmnioPatch™ is a surgical allograft derived from human amniotic membrane that is a protective covering and physical barrier from external irritants. Amniotic membrane also contains collagen, fibronectin, and hyaluronic acid, along with a combination of growth factors, cytokines, and anti-inflammatory proteins such as interleukin-1 receptor antagonist.

Stem Cells

Stem cell therapy is another revolutionary technique to facial rejuvenation. The stem cells can be harvested from bone marrow or from fat tissue of the lower abdominal area and placed back into skin by injection. The patients treated have exhibited marked improvement not only in the underlying soft tissue contours of the face but the skin itself.  Stem cells can be injected by itself alone or combination with PRP. 

Treatment of Stem Cells

The potential benefits of PRP and stem cells have led to a recent widespread interest in its use for anti-aging and regenerative purposes. The healing properties of the blood components in PRP and stem cells can be used as a cosmetic treatment for the following:

  • Reducing fine lines and wrinkles

  • Tightening and toning skin

  • Mild collagen and volume loss

  • Crow’s feet and dark under eye circles

  • Acne scarring

  • Rosacea

 

Within a few weeks of treatment, an overall improvement in skin hydration, texture and tone can be seen. New collagen and blood vessels begin to grow after three to six weeks, and reduction of fine lines and wrinkles and volume correction happens over the next three to six months. The effects of Cosmetic PRP can last 12 months to two years, depending on the individual. While it creates a longer-lasting effect in the skin, it does take time to work. For women looking for an immediate effect, Cosmetic PRP can be combined with hyaluronic acid fillers for quick volume correction. Fillers provide a matrix for building new collagen and can be used to accelerate and sustain the benefits of Cosmetic PRP.

Derived from donated placentas, a simple 15-minute procedure with our products StemShot®, and AmnioShot™️ can begin a healing process that lasts a lifetime. Unlike pain-relieving shots, our products aren’t intended to mask pain — they help restore and repair injured tissue.

“Recent preclinical and clinical research shows that stem cells can play a role in tissue repair and regeneration. This discovery has led to many treatment applications in several fields, such as cardiovascular, neurology, gastrointestinal, renal, orthopedic, and hematology. Significant promising evidence shows that stem cells are capable of delivering a plethora of regenerative and anti-inflammatory properties.” – The Institute of Stem Cell Therapy

More on stem cell therapies from the Institute of Stem Cell Therapy:

 

How Do Stem Cells Work, and What Are Their Capabilities?

It’s important to understand that stem cells are only one, a single component that catalyzes many larger cellular components — a plethora of nucleated cells. When stem cells are put into the body, they are innately attracted to damaged cells. This is because damaged cells in your body give off a chemical signal in their vicinity, known as the paracrine space. Stem cells will attach themselves to a nearby blood vessel, where they can function as pericytes. Pericytes are cells that give nutritional support to the damaged cells, with the goal of regenerating them back to their normal, functioning condition.
Perhaps one of the most important aspects of the stem cell is its natural anti-inflammatory effect. When a tissue injury is inflicted, a spectrum of biochemical reactions erupts at the injured site — whether that’s a joint or soft tissue. Within that spectrum of biochemical reactions is the production of tumor necrosis factor alpha (TNF alpha) and interferon gamma, as well as interleukins 1, 2, and 12. These are known as type 1 helper (Th1) cells, and they’re necessary for the inflammatory process to take place.

 

Anti-inflammatory Proteins and Immunomodulatory Cytokines

Mesenchymal stem cells also deliver a plethora of anti-inflammatory proteins and immunomodulatory cytokines, including: prostaglandin E2 (PGE2, also known as dinoprostone), which relaxes smooth muscle, tissue-growth factor beta 2 (TGFB2), hepatocyte growth factor (HGF), nitric oxide, interleukins 4, 6, and 10, and many more. They also deliver an essential protein called Interleukin-1 Receptor Antagonist (also known as IL-1RA) — these function as type 2 helper (Th2) cells that aid significantly in balancing the inflammatory process. This is important, as nearly all autoimmune disorders are T1 weighted, meaning they’re pro-inflammatory disorders. Umbilical cord-derived stem cells have the ability to rapidly modulate these T1 and T2 helper cells so that they discontinue their attack on the body. Remember, IL-1 is pro-inflammatory; thus, IL-1RA inhibits the expression of IL-1, or the inflammatory process. This makes IL-1RA an incredibly efficient natural inhibitor of inflammation. Additionally, it inhibits tumor necrosis factor alpha, which is indicated in many autoimmune diseases.

 

Anti-Apoptotic and Antimicrobial Effects

Another major function of stem cells is their anti-apoptotic effect. Apoptosis is defined as programmed cell death, and as cells get old and cease to function properly (called senescence cells), eventually they collapse their cell walls and expel the DNA stored. Stem cells have the remarkable capacity to give trophic support to the senescence cell (the aged cell that is no longer functioning correctly) and restore it to a functioning state. And, when one cell functions in a healthy state, it aids in keeping the cells around it functioning correctly.


Furthermore, a recent new and exciting use of stem cells is for their antimicrobial effects. Stem cells are programmed with innate immune defense against microbial infections, which comes from a handful of polypeptides. There are also studies being done against acute, chronic, and even significant systemic infections, to which there has reportedly been an excellent response.

Informational References

  1. Mao AS, Mooney DJ. Regenerative medicine: Current therapies and future directions. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(47):14452-14459. doi:10.1073/pnas.1508520112.

  2. Schultz M. Rudolf Virchow. Emerging Infectious Diseases. 2008;14(9):1480-1481. doi:10.3201/eid1409.086672.

  3. National Institute of Biomedical Imaging and Bioengineering Staff. Tissue Engineering and regenerative medicine. National Institute of Health. https://www.nibib.nih.gov/science-education/science-topics/tissue-engineering-and-regenerative-medicine.

  4. Nelson CM, Bissell MJ. Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2006;22:287–309. https://www.annualreviews.org/doi/10.1146/annurev.cellbio.22.010305.104315.

  5. Kolambkar YM, et al. An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials. 2011;32(1):65–74. doi:10.1016/j.biomaterials.2010.08.074.

  6. Dewan AK, Gibson MA, Elisseeff JH, Trice ME. Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. BioMed Res Int. 2014;2014:272481. doi:10.1155/2014/272481.

  7. Huebsch N, Mooney DJ. Inspiration and application in the evolution of biomaterials. Nature. 2009;462(7272):426–432. doi:10.1038/nature08601.

  8. Gilpin A, Yang Y. Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications. BioMed Research International. 2017;2017:9831534. doi:10.1155/2017/9831534.

  9. Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. Journal of Orthopaedic Surgery and Research. 2014;9:18. doi:10.1186/1749-799X-9-18.

  10. Roh JD, Sawh-Martinez R, Brennan MP, et al. Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(10):4669-4674. doi:10.1073/pnas.0911465107.

  11. Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature medicine. 2010;16(7):814-820. doi:10.1038/nm.2170.

  12. Goh S-K, Bertera S, Olsen P, et al. Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering. Biomaterials. 2013;34(28):6760-6772. doi:10.1016/j.biomaterials.2013.05.066.

  13. Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006;367(9518):1241–1246. https://www.ncbi.nlm.nih.gov/pubmed/16631879.

  14. Petersen TH, Calle EA, Zhao L, et al. Tissue-Engineered Lungs for in Vivo Implantation. Science (New York, NY). 2010;329(5991):538-541. doi:10.1126/science.1189345.

  15. O’Brien T, Barry FP. Stem cell therapy and regenerative medicine. Mayo Clinic Proceedings. 2009;84(10):859-861. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755803/.

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